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welcomeWelcome Chen Leibson to the lab. Chen starts an MSc program working on archaic splicing patterns.

nuclear miRNAs Our joint project with Profs. Ruth Sperling and Michal Linial has been now published in Nucleic Acids Research. In this work, we report hundreds of mature miRNAs, as well as well-defined fragments of pre-miRNAs, that are present within spliceosomes and potentially have nuclear functions.

Shelly Mahlab-Aviv et al. (2018). Small RNA sequences derived from pre-microRNAs in the supraspliceosome,Nucleic Acids Research, advanced publication.

Conference Liran gave a talk at SMBE 2018 held in Yokohama, Japan. Liran talked about reconstructing the Denisovan anatomy based on DNA methylation patterns.

Conference Liran gave a talk at the Conference "What makes us human: from genes to machines", held in Jerusalem, at the brand new Suzanne and Charles Goodman Brain Sciences Building. You are welcome to watch on youtube.

Interview Yoav was interviewed in "The World Today" on Mammoth research(in Hebrew). Follow on youtube.

Research Interests:
Our lab deals with a host of topics in the general fields of molecular evolution and genetics. Among the topics that are currently pursued are:
  • Human evolution. Recent advances in ancient DNA sequencing yielded genomes (either shotgun sequences with varying degrees of coverage, or SNP arrays) of many ancient anatomically modern humans, as well as of Neanderthals and Denisovans. This open unique opportunities to study the genetic aspects of the very recent lag of our own evolution.
  • Paleo-epigenetics. We developed a technique to reconstruct full DNA methylation maps from high-coverage ancient genomes, and use it to study evolutionary changes in gene regulation, ancient environments and phenotypic adaptations.
  • Paleo-genetics. We study the genetic structure of ancient populations in Israel.
  • RNA biology. We are studying many aspects of RNA biology, including splicing, nonsense-mediated decay, 3'-end processing, and circular RNAs.
  • Multivariate data analysis. My lab is also active in some fields of applied mathematics: multivariate analysis, statistical pattern recognition, data visualization, and machine learning.
A quick summary of our research on archaic gene regulation. A narration accompanied by whiteboard animation.

Interview Liran was interviewed in the "Three that Know" radio show on the Neanderthalized mini-brains project declared by Svante Paabo (in Hebrew).

Interview Yoav Mathov was interviewed in Makademia.

MovieLiran was interviewed at London et Kirshenbaum about Otzi's helicobacter. Minutes 29:42 to 34:33.

Our Web Servers
Movie Gene ORGANizer connects genes to the body parts where their phenotype is observed. Given a list of genes, Gene ORGANizer finds body parts in which these genes are enriched or depleted. The paper is about to appear in the webserver issue of NAR, but can already be found online.

Movie JuncDB is a gene exon-intron architecture comparative database, covering nearly 40,000 sets of orthologous transcripts across 88 eukaryotic species. It had been published in the database issue of NAR.
Contact Information:
Room 2-342
Department of Genetics, The Alexander Silberman Institute of Life Sciences, Faculty of Science,
the Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel
telephone +972 (2) 658-5103
fax +972 (2) 658-4856
email liran.carmel @
The Hebrew University
Useful links: for more details and full list