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Rector AwardLiran is the 2022 recipient of the Hebrew University Rector's Award for excellence in research.

conferenceLiran gave a talk at the annual meeting of the Israel Society for Evolutionary Biology, that was held at Weizmann Institute, Rehovot, Israel.

Massry PrizeLiran is the 2021 Massry Prize laureate. The Massry Prize is endowed every year to research who contributed significantly to a specific topic. The topic of this year is ancient DNA. The laureates are selected by a committee of distinguished professors from the University of Southern California (USC) and the University of California, Los Angeles (UCLA). the ceremony took place in Beverly Hills, CA.

farewell We all say goodbye to Lily, who is leaving for a postdoc in Stanford, with Noah Rosenberg, where she will be working on theoretical population genetics. Lily completed with us her second PhD in statistics, and stayed for another year as a postdoctoral student. We wish her good luck in Stanford!

farewell We all say goodbye to Avigayel, who submitted her PhD thesis. Avigayel worked on the quantification and evolution of circular RNAs in Drosophila. Avigayel has now turned to the industry. Good luck Avigayel.

welcomeWe welcome Krystal White to the lab! Krystal came from the US to carry out a M.Sc. with us, working on improvements to methods to reconstruct ancient methylation. Good luck!

Rabin2021 Avigayel's paper on the identification and annotation of circular RNAs has been published. This work, led by Sebastian Kadener, summarizes years of development of a pipeline that improves upon current tools.

Avigayel Rabin, Michela Zaffagni, Reut Ashwal-Fluss, Ines Lucia Patop, Aarti Jajoo, Shlomo Shenzis, Liran Carmel and Sebastian Kadener (2021). SRCP: a comprehensive pipeline for accurate annotation and quantification of circRNAs. Genome Biology 22:277

Oren2021 We helped Batsheva Kerem and her group to compute the effects of different antisense oligonucleotides on splicing of the CTRF gene. This might become useful in curing cystic fibrosis patient with a certain mutation.

Yifat S. Oren, Michal Irony-Tur Sinai, Anita Golec, Ofra Barchad-Avitzur, Venkateshwar Mutyam, Yao Li, Jeong Hong, Efrat Ozeri-Galai, Aurélie Hatton, Chen Leibson, Liran Carmel, Joel Reiter, Eric J. Sorscher, Steve D. Wilton, Eitan Kerem, Steven M. Rowe, Isabelle Sermet-Gaudelus, Batsheva Kerem (2021). Antisense oligonucleotide-based drug development for Cystic Fibrosis patients carrying the 3849+10kb C-to-T splicing mutation. Journal of Cystic Fibrosis 2::S1569-1993(21)01287-X.

ChairLiran is now the Snyder Granadar chair in Genetics!

welcomeWe welcome Yael Riback, our new administrator, to the lab! Wishing Yael a fruitful and enjoyable time in the lab.

welcomeWe welcome Arielle Barouch to the lab. Arielle is starting masters in the lab, under the joint supervision of Benny Yakir.

conferenceLiran was (virtually) invited to talk at Expanding Minds - the Allen Institute conference on human brain evolution.

Research Interests:
Our lab deals with a host of topics in the general fields of molecular evolution and genetics. Among the topics that are currently pursued are:
  • Human evolution. Recent advances in ancient DNA sequencing yielded genomes (either shotgun sequences with varying degrees of coverage, or SNP arrays) of many ancient anatomically modern humans, as well as of Neanderthals and Denisovans. This open unique opportunities to study the genetic aspects of the very recent lag of our own evolution.
  • Paleo-epigenetics. We developed a technique to reconstruct full DNA methylation maps from high-coverage ancient genomes, and use it to study evolutionary changes in gene regulation, ancient environments and phenotypic adaptations.
  • Paleo-genetics. We study the genetic structure of ancient populations in Israel.
  • RNA biology. We are studying many aspects of RNA biology, including splicing, nonsense-mediated decay, 3'-end processing, and circular RNAs.
  • Multivariate data analysis. My lab is also active in some fields of applied mathematics: multivariate analysis, statistical pattern recognition, data visualization, and machine learning.
Our Web Servers
Movie Gene ORGANizer connects genes to the body parts where their phenotype is observed. Given a list of genes, Gene ORGANizer finds body parts in which these genes are enriched or depleted.

Gokhman D, Kelman G, Amartely A, Gershon G, Tsur S, Carmel L (2017). Gene ORGANizer: Linking Genes to the Organs They Affect. Nucleic Acids Research 45(W1) (Web server issue):W138-W145.

Movie JuncDB is a gene exon-intron architecture comparative database, covering nearly 40,000 sets of orthologous transcripts across 88 eukaryotic species.

Chorev M, Guy L, Carmel L (2016). JuncDB: an exon-exon junction database. Nucleic Acids Research 44(D1) (Database issue):D101-D109.

Recent Media Events
Interview Liran was interviewed in the "Three who Know" radio show on the functional implications of the sequence difference in TKTL1 between modern humans and Neanderthals.

Liran was featured in a documentary film on the Denisovans, directed by Guy Beauché, written by Emilie Martin & Fabrice Papillon, © Galaxie/France télévisions 2022.

Interview Liran was interviewed in the "Three who Know" radio show on the study that reported that milk usage alone cannot explain the spread of the lactose-tolerance mutation. The authors claim that selection works mainly during times of disease or famine spread, and not continuously.
Interview Liran was interviewed in the "Three who Know" radio show on the first human nuclear DNA sequenced from a victim of the Pompeii volcanic eruption. Overall, the sequenced individual was genetically very similar to other contemporary individuals from the area.

Amazing! A whole episode of PBS Eons dedicated to our work!

'This week' podcast of Ha'aretz, a weekly podcast with Lior Kodner. Liran talked about the ethical code in ancient DNA research. The relevant part starts at 35:00.

Interview Liran was interviewed in the "Three who Know" radio show on the evolution of polygenic characters in the past 3,000 years of human evolution.

Interview Liran was interviewed in the "Three who Know" radio show on the recent discovery of the Harbin skull. For the relevant part, go to minute 15:45.

ynet An article on our work with Yigal Erel on lead pollution in bones through historical times
Interview Liran was interviewed in the "Three who Know" radio show on the recent analysis of sources of polymorphism in the human genome.

Interview Liran was interviewed in the "Three who Know" radio show on two works that sequenced ancient DNA from the first Homo sapiens who arrived to Europe..

A quick summary of our research on archaic gene regulation. A narration accompanied by whiteboard animation.

Contact Information:
Room 3-615
Department of Genetics, The Alexander Silberman Institute of Life Sciences, Faculty of Science,
the Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel
telephone +972 (2) 658-5103
fax +972 (2) 658-4856
email liran.carmel @
The Hebrew University for more details and full list